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| Torki,Akram; Khalaji-Pirbalouty,Valiallah; Lorigooini,Zahra; Rafieian-Kopaei,Mahmoud; Sadeghimanesh,Arezo; Rabiei,Zahra. |
| Abstract Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in the rat. To do so, 50 rats were randomly assigned to five groups; control, sham, ischemia, and 50 or 100 mg/kg of Anchusa italica treated animals. Ischemia was induced by occlusion of carotid artery for 30 minutes. Afterward, behavioral tests and biochemical analyses were conducted. Induction of ischemia/reperfusion caused a decline in learning and passive avoidance memory in rats.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Boraginaceae/phytochemistry; Brain ischemia; Spatial memory/drug effects; Malondialdehyde/pharmacology; Neuroprotection/drug effects; Lipidic peroxidation/drug effects; Antioxidant capacity; Passive avoidance memory.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100613 |
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| Esfandyari,Zahra; Mirazi,Naser; Sarihi,Abdolrahman; Rafieian-Kopaei,Mahmoud. |
| ABSTRACT: Pain is a normal protective response to tissue injury caused by physical trauma, noxious chemicals and microbiological agents. Use of chemical drugs and medicinal plants is a conventional method to manage pain; however, their side effects have caused increased tendency to the use of herbal medicines among patients. This study was conducted to investigate antinociceptive action of Ricinus communis seed’s extract (RCE) in male Balb/C mice. In this experimental study, 72 male mice weighing 25-35gr were used. Animals were randomly divided into six groups of 12 mice each, including: Control group, three groups separately treated respectively with 100, 200, and 400mg/kg hydroethanolic R. communis seed extract, morphine (1mg/kg)-treated group, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antinociception; Ricinus communis; Morphine; Mice. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000600601 |
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